American Airlines has round-trip flights from Los Angeles (LAX) to Sao Paulo (GRU) for $404 with a connection. Flights May to June. No Friday departures. Origin/Destination reversible.
This is the lowest price seen in the past 4-years for LAX-GRU on American, a full-service carrier. (Other deals were on budget carriers like LATAM, Copa, or Avianca)
Previous low was $286-$366 on Delta back in November 12th, 2020.
A Carry-on bag and also a personal item is allowed for free on American. You can avoid paying for seat selection by accepting the randomly assigned seat at the gate.
Click for more details and booking links Cheap Flights: Los Angeles to/from Sao Paulo $404 r/t [May-June] – American Airlines